| District | Incumbent | Party | PVI | Age | Notes |
|---|---|---|---|---|---|
| AL-02 | Everett | R | R+13.2 | 71 | Retiring |
| AZ-01 | Renzi | R | R+2.2 | 50 | Retiring |
| CA-04 | Doolittle | R | R+10.9 | 58 | Retiring |
| CA-12 | Lantos | D | D+22.5 | 80 | Retiring |
| CA-52 | Hunter | R | R+9.3 | 60 | Running for President |
| CO-02 | Udall | D | D+8.1 | 58 | Running for Senate |
| CO-06 | Tancredo | R | R+10 | 62 | Running for President |
| IL-11 | Weller | R | R+1.1 | 51 | Retiring |
| IL-18 | LaHood | R | R+5.5 | 62 | Retiring |
| LA-04 | McCrery | R | R+6.5 | 59 | Retiring |
| ME-01 | Allen | D | D+6.2 | 63 | Running for Senate |
| MN-03 | Ramstad | R | R+0.5 | 62 | Retiring (?) |
| MS-03 | Pickering | R | R+14.1 | 45 | Retiring |
| NJ-03 | Saxton | R | D+3.3 | 60 | Retiring |
| NJ-07 | Ferguson | R | R+0.6 | 38 | Retiring |
| NM-01 | Wilson | R | D+2.4 | 47 | Running for Senate |
| NM-02 | Pearce | R | R+5.7 | 61 | Running for Senate |
| NM-03 | Udall | D | D+5.5 | 60 | Running for Senate |
| NY-21 | McNulty | D | D+8.7 | 61 | Retiring |
| NY-25 | Walsh | R | D+3.4 | 61 | Retiring |
| OH-07 | Hobson | R | R+6.0 | 72 | Retiring |
| OH-15 | Pryce | R | R+1.1 | 57 | Retiring |
| OH-16 | Regula | R | R+3.6 | 84 | Retiring |
| PA-05 | Peterson | R | R+9.7 | 69 | Retiring |
| WY-AL | Cubin | R | R+19.4 | 61 | Retiring |
*Denotes impending special election
| District | Incumbent | Party | PVI | Age | Notes |
|---|---|---|---|---|---|
| IL-14 | Hastert | R | R+4.8 | 67 | Resigned* |
| LA-01 | Jindal | R | R+18.5 | 37 | Elected Governor* |
| LA-06 | Baker | R | R+6.5 | 60 | Cashing In* |
| MS-01 | Wicker | R | R+10.0 | 57 | Appointed to the Senate* |
| District | Incumbent | Party | PVI | Age | Notes |
|---|---|---|---|---|---|
| AK-AL | Young | R | R+14.3 | 75 | Under investigation |
| CA-24 | Gallegly | R | R+4.8 | 64 | Botched a retirement attempt in 2006 |
| CA-41 | Lewis | R | R+9.0 | 74 | Under investigation |
| CO-05 | Lamborn | R | R+15.7 | 54 | Primary challenge |
| DE-AL | Castle | R | D+6.5 | 69 | Health issues |
| FL-10 | Young | R | D+1.1 | 78 | Age issues/Speculation |
| GA-10 | Broun | R | R+12.7 | 61 | Primary challenge |
| IA-03 | Boswell | D | D+1.4 | 74 | Health issues/Primary challenge |
| IL-03 | Lipinski | D | D+10.3 | 42 | Primary challenge |
| LA-02 | Jefferson | D | D+27.8 | 61 | Indicted |
| MD-01 | Gilchrest | R | R+9.8 | 62 | Primary challenge |
| MD-04 | Wynn | D | D+29.8 | 57 | Primary challenge |
| MD-06 | Bartlett | R | R+12.8 | 82 | Age issues |
| MO-06 | Graves | R | R+4.8 | 44 | Potential gubernatorial run |
| MO-08 | Emerson | R | R+11.0 | 58 | Potential gubernatorial run |
| MO-09 | Hulshof | R | R+6.5 | 50 | Potential gubernatorial run |
| MI-03 | Ehlers | R | R+9.0 | 74 | Speculation |
| NC-09 | Myrick | R | R+12.2 | 67 | Speculation |
| NY-23 | McHugh | R | R+0.2 | 60 | Speculation |
| OH-02 | Schmidt | R | R+13.1 | 56 | Primary challenge |
| TN-09 | Cohen | D | D+18.1 | 59 | Primary challenge |
| TX-04 | Hall | R | R+17.1 | 85 | Age issues/Primary challenge |
| VA-11 | Davis | R | R+0.6 | 59 | Mulling retirement |